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pentobarbital will reduce the level or outcome of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.Monitor Closely (one)pentobarbital will lower the level or effect of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with